The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness

Abstract Many genes encoding chromatin proteins are subject to evolutionary selection driving reproductive fitness. In mice and men, the H3f4 / H3-4 gene encoding the histone H3.4 variant (formerly known as H3t) is essential to spermatogenesis. Here we define the evolutionary origin and molecular-ph...

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Hauptverfasser:	Pavel A. Komarov, Philipp C. Bammer, Ching-Yeu Liang, Hans-Rudolf Hotz, Grigorios Fanourgakis, Sunwoo Chun, Hubertus Kohler, Tim-Oliver Buchholz, Jean-Francois Spetz, Antoine H.F.M. Peters
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-06-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-026-73954-9
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