Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a promising RSV-vaccine immunogen, capable of b...

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Detalhes bibliográficos

Principais autores:	M. Gordon Joyce, Amy Bao, Man Chen, Ivelin S. Georgiev, Li Ou, Tatsiana Bylund, Aliaksandr Druz, Wing-Pui Kong, Dongjun Peng, Emily J. Rundlet, Joseph G. Van Galen, Shuishu Wang, Yongping Yang, Baoshan Zhang, Gwo-Yu Chuang, Jason S. McLellan, Barney S. Graham, John R. Mascola, Peter D. Kwong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Case Western Reserve University 2019-12-01
coleção:	Pathogens and Immunity
Assuntos:	antigenic site crystal structure epitope fusion glycoprotein immunogenicity neutralization rsv subtype vaccine
Acesso em linha:	https://paijournal.com/index.php/paijournal/article/view/338
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