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Deletion of Tgf‐β1 From CD206+ M2 Macrophages Ameliorates Obesity‐Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle

ABSTRACT Backgrounds Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood. M2 macrophages within skeletal...

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Principais autores: Muhammad Bilal, Le Duc Anh, Nguyen Quynh Phuong, Sana Khalid, Allah Nawaz, Memoona, Muhammad Rahil Aslam, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Aamir Sharif, Yasuhiro Onogi, Tsutomu Wada, Ryuji Hayashi, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-06-01
coleção:Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
M2 macrophage‐derived Tgf‐β1
mitochondrial function
muscle dysfunction
sarcopenic obesity
Acesso em linha:https://doi.org/10.1002/jcsm.70322
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