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Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarization

Abstract Background Cyclophosphamide (CTX) -induced ovarian fibrosis is involved in premature ovarian failure (POF). While metformin has demonstrated anti-fibrotic properties, the mechanism by which it regulates fibroblast activation, the primary effector cells in fibrosis, remains unclear in POF. M...

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Principais autores: Ping Nie, Bo Yao, Zhejun Zhang, Jingling Li, Minghua Wang, Gendie E. Lash, Bihui Guo, Ping Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:Journal of Translational Medicine
Fag:
MIF
CD74
Fibroblasts
Fibrosis
Premature ovarian failure
Online adgang:https://doi.org/10.1186/s12967-025-07294-5
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