Data-driven modeling predicts gene regulatory network dynamics during the differentiation of multipotential hematopoietic progenitors.
Cellular differentiation during hematopoiesis is guided by gene regulatory networks (GRNs) comprising transcription factors (TFs) and the effectors of cytokine signaling. Based largely on analyses conducted at steady state, these GRNs are thought to be organized as a hierarchy of bistable switches,...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2022-01-01
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| coleção: | PLoS Computational Biology |
| Acesso em linha: | https://doi.org/10.1371/journal.pcbi.1009779 |
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