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Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum

Abstract Background Alzheimer’s disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper un...

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Principais autores: Johan Gobom, Andréa L. Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-12-01
coleção:Molecular Neurodegeneration
Assuntos:
Tau
Phosphorylation
Alzheimer’s disease
LC–MS
Cerebrospinal fluid
Acesso em linha:https://doi.org/10.1186/s13024-022-00586-0
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