Kinetics of Abacavir-Induced Remodelling of the Major Histocompatibility Complex Class I Peptide Repertoire

Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the HLA-B*57:01 antigen binding cleft, leading to the...

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Principais autores:	Patricia T. Illing, Andy van Hateren, Rachel Darley, Nathan P. Croft, Nicole A. Mifsud, Samuel King, Lyudmila Kostenko, Mandvi Bharadwaj, James McCluskey, Tim Elliott, Anthony W. Purcell
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2021-05-01
Serija:	Frontiers in Immunology
Teme:	MHC I antigen presentation abacavir T cells drug hypersensitivity immunopeptidome tapasin
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.672737/full
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