The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition

T lymphocytes are stimulated when they recognize short peptides bound to class I proteins of the major histocompatibility complex (MHC) protein, as peptide–MHC complexes. Due to the diversity in T-cell receptor (TCR) molecules together with both the peptides and MHC proteins they bind to, it has bee...

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Autori principali:	R. Charlotte Eccleston, Shunzhou Wan, Neil Dalchau, Peter V. Coveney
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2017-07-01
Serie:	Frontiers in Immunology
Soggetti:	pathway model binding affinity machine learning molecular dynamics MHC-I antigen presentation pathway
Accesso online:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00797/full
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