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Gamabufotalin suppresses pancreatic cancer through redox-homeostasis disruption by G6PD downregulation

Abstract Background Pancreatic cancer is a leading cause of cancer-related deaths worldwide, highlighting the critical need for novel therapeutic strategies. Gamabufotalin (CS-6), a bufadienolide compound, has been shown to exert significant inhibitory effects on a variety of cancers. Objective This...

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Principais autores: Die Xu, Xiaowei Wang, Yisi Cai, Piao Zheng, Lemei Zhu, Weijun Peng, Yinghui Song, Bolin Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-06-01
coleção:Journal of Translational Medicine
Assuntos:
Pancreatic cancer
Gamabufotalin
G6PD
Oxidative stress
Autophagy
Acesso em linha:https://doi.org/10.1186/s12967-026-08441-2
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