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Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity

GBA1 gene encodes for the lysosomal membrane protein glucocerebrosidase (GCase). GBA1 heterozygous mutations profoundly impair GCase activity and are currently recognized as an important risk factor for the development of Parkinson's disease (PD). Deficits in lysosomal degradation pathways may contr...

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Principais autores: Liudmila Mus, Francesca Siani, Claudio Giuliano, Christina Ghezzi, Silvia Cerri, Fabio Blandini
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019-04-01
Series:Neurobiology of Disease
Assuntos:
Glucocerebrosidase
α-Synuclein
CBE
MPTP
Parkinson's disease
Mouse model
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S0969996118307563
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