Inhibition of fucosylation in human invasive ductal carcinoma reduces E‐selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

Breast cancer tissue overexpresses fucosylated glycans, such as sialyl‐Lewis X/A (sLeX/A), and α‐1,3/4‐fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E‐selectin, initiating tumor extravasati...

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Detalhes bibliográficos

Principais autores:	Mylène A. Carrascal, Mariana Silva, José S. Ramalho, Cláudia Pen, Manuela Martins, Carlota Pascoal, Constança Amaral, Isabel Serrano, Maria José Oliveira, Robert Sackstein, Paula A. Videira
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2018-05-01
coleção:	Molecular Oncology
Assuntos:	breast cancer cell migration fucosylation proliferation sialyl‐Lewis X/A
Acesso em linha:	https://doi.org/10.1002/1878-0261.12163
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