Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability
Abstract Synthetic macrocycles offer exceptional potential as therapeutics. However, most high-throughput discovery platforms rely on genetically encoded libraries of large peptide macrocycles, which typically are not optimized for drug like properties. Fully synthetic libraries offer greater flexib...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2026-04-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-026-71641-3 |
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