The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of <i>Aspergillus fumigatus</i>
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of DNA and RNA; thus, inhibition of their synthesis i...
Uloženo v:
| Hlavní autoři: | , , , , , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
MDPI AG
2020-04-01
|
| Edice: | Journal of Fungi |
| Témata: | |
| On-line přístup: | https://www.mdpi.com/2309-608X/6/2/47 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|