Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.

Abstract: In Gaucher disease (GD), the deficiency of glucocerebrosidase causes lysosomal accumulation of glucosylceramide (GlcCer), which is partly converted by acid ceramidase to glucosylsphingosine (GlcSph) in the lysosome. Chronically elevated blood and tissue GlcSph is thought to contribute to s...

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מידע ביבליוגרפי

Principais autores:	Lindsey T. Lelieveld, Sophie Gerhardt, Saskia Maas, Kimberley C. Zwiers, Claire de Wit, Ernst H. Beijk, Maria J. Ferraz, Marta Artola, Annemarie H. Meijer, Christian Tudorache, Daniela Salvatori, Rolf G. Boot, Johannes M.F.G. Aerts
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2022-05-01
סדרה:	Journal of Lipid Research
נושאים:	Gaucher disease acid ceramidase lipid metabolism zebrafish glucosylceramide sphingolipids
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S0022227522000323
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