Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop

Ebolavirus (EBOV) is a negative-sense RNA virus that causes severe hemorrhagic fever in humans. The matrix protein VP40 facilitates viral budding by binding to lipids in the host cell plasma membrane and driving the formation of filamentous, pleomorphic virus particles. The C-terminal domain of VP40...

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Principais autores:	Kristen A. Johnson, Nisha Bhattarai, Melissa R. Budicini, Carolyn M. LaBonia, Sarah Catherine B. Baker, Bernard S. Gerstman, Prem P. Chapagain, Robert V. Stahelin
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-07-01
Series:	Viruses
Assuntos:	ebolavirus lipid-protein interaction matrix protein membrane bilayer membrane binding oligomerization
Acceso en liña:	https://www.mdpi.com/1999-4915/13/7/1375
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