Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes

Flavonoids are abundant polyphenols in nature. They are extensively biotransformed in enterocytes and hepatocytes, where conjugated (methyl, sulfate, and glucuronide) metabolites are formed. However, bacterial microflora in the human intestines also metabolize flavonoids, resulting in the production...

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Detalhes bibliográficos

Principais autores:	Violetta Mohos, Eszter Fliszár-Nyúl, Beáta Lemli, Balázs Zoltán Zsidó, Csaba Hetényi, Přemysl Mladěnka, Pavel Horký, Milan Pour, Miklós Poór
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-03-01
coleção:	Biomolecules
Assuntos:	polyphenols colonic flavonoid metabolites pharmacokinetic interaction serum albumin cyp450 enzymes resorcinol phloroglucinol o-desmethylangolensin
Acesso em linha:	https://www.mdpi.com/2218-273X/10/3/409
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