Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model

<p>Abstract</p> <p>Background</p> <p>Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly understood.</p> <p>Methods</p> <p>We produced pCX-shh-IG...

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Detalhes bibliográficos

Principais autores:	Chang Chin-Pao, Chen Ying-Yu, Tsao Zih-Jay, Wu Chia-Yung, Chen Bo-Yie, Chang Han-Hsin, Yang Chi-Rei, Lin David
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2011-01-01
coleção:	Journal of Biomedical Science
Acesso em linha:	http://www.jbiomedsci.com/content/18/1/6
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