A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)

How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulat...

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Hlavní autoři:	Xavier Renaudin, Ashok R. Venkitaraman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2021-11-01
Edice:	Molecular & Cellular Oncology
Témata:	oxidative stress mitochondria rna-dna hybrid r-loops mtdna replication brca2 setx prpf8 cancer neurodegeneration genomic instability
On-line přístup:	http://dx.doi.org/10.1080/23723556.2021.2007028
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