The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation

Excitotoxicity due to excessive activation of glutamate receptors is a primary mediator of cell death in acute and chronic neurological disorders, and NMDA-type glutamate receptors (NMDARs) are thought to be involved. NMDARs assemble from heteromeric combinations of GluN1, GluN2 and GluN3 subunits,...

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Auteurs principaux:	Rebeca Martínez-Turrillas, Elena Puerta, Dhrubajyoti Chowdhury, Sonia Marco, Masahiko Watanabe, Norberto Aguirre, Isabel Pérez-Otaño
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2012-12-01
Collection:	Neurobiology of Disease
Sujets:	GluN3A Neuroprotection Calpain Extrasynaptic NMDA receptors 3-nitropropionic acid Huntington’s disease
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0969996112002422
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