Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Abstract Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The methodology of building a multi-route PBPK model for NPs has not been established, nor systematically evaluated. In this...

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Автори:	Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling, Zhoumeng Lin
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2022-07-01
Серія:	Particle and Fibre Toxicology
Предмети:	Biodistribution Endocytosis Gold nanoparticles Nanomedicine Nanotoxicology Physiologically based pharmacokinetic (PBPK) modeling
Онлайн доступ:	https://doi.org/10.1186/s12989-022-00489-4
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