P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage

Abstract Background Subarachnoid hemorrhage (SAH) is a common acute condition in neurosurgery, with microglial function playing a crucial role in determining patient outcomes. However, the involved mechanisms are complex and demand thorough investigation. In our study, we combined transcriptomic and...

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Auteurs principaux:	Peng-Fei Ding, Jia-Tong Zhang, Xiao-Long Zhu, Yue Cui, Chun-Lei Chen, Xun-Zhi Liu, Jun-Da Shen, Le-Xuan Zou, Yue Lu, Zong Zhuang, Chun-Hua Hang, Wei Li
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-08-01
Collection:	Journal of Neuroinflammation
Sujets:	Subarachnoid hemorrhage 5-LOX LTB4/LXA4 ratio Ca2+ P2X7-CaMKII
Accès en ligne:	https://doi.org/10.1186/s12974-025-03530-3
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