Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine’s Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes

Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co-administered drugs. Additionally, CBZ exhibits nonline...

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Autori principali:	Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-05-01
Serie:	Pharmaceutics
Soggetti:	physiologically based pharmacokinetic (PBPK) modeling Drug–Drug Interaction (DDI) carbamazepine Carbamazepine-10,11-epoxide induction cytochrome P450 3A4 (CYP3A4)
Accesso online:	https://www.mdpi.com/1999-4923/16/6/737
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