Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models

PurposeThe National Cancer Institute’s Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT) randomized phase 2 clinical trial assessed the utility of applying tumor DNA sequencing to treatment selection. Here, we report the results of a companion preclinical study in patient-derived xe...

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Autori principali:	Yvonne A. Evrard, Sergio Y. Alcoser, Michael Mullendore, Li Chen, Chih-Jian Lih, Vishnuprabha Rahul Kannan, Vivekananda Datta, Lindsay Dutko, Shahanawaz Jiwani, Lawrence V. Rubinstein, Yingdong Zhao, P. Mickey Williams, Alida Palmisano, Laura Kuhlmann, Mel Simpson, Shivaani Kummar, Biswajit Das, Chris Karlovich, Eric Polley, Ming-Chung Li, Alice P. Chen, Melinda G. Hollingshead, James H. Doroshow
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-05-01
Serie:	Frontiers in Oncology
Soggetti:	precision medicine NCI-MPACT patient-derived models DNA damage repair next-generation sequencing targeted agents
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1571635/full
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