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Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study

Abstract Background Acute pulmonary embolism (PE) is a leading cause of cardiovascular death, primarily due to abrupt increased pulmonary vascular resistance (PVR) leading to acute right ventricular (RV) failure. Ketone bodies, especially 3-hydroxybutyrate (3-OHB), have shown potential to increase c...

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Principais autores: Mads Dam Lyhne, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Simone Juel Dragsbaek, Casper Homilius, Jacob Seefeldt, Jacob Valentin Hansen, Anders Dahl Kramer, Lasse Juul Christensen, Mark Stoltenberg Ellegaard, Oskar Kjærgaard Hørsdal, Andreas Overgaard, Alexander Møller Larsen, Ebbe Boedtkjer, Asger Andersen, Roni Nielsen
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2025-12-01
coleção:Intensive Care Medicine Experimental
Assuntos:
Right ventricular function
Pulmonary circulation
Pulmonary vascular resistance
Myography
Vasorelaxation
3-Hydroxybutyrate
Acesso em linha:https://doi.org/10.1186/s40635-025-00844-7
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