Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling

The transition of human embryonic stem cells (hESCs) from pluripotency to lineage commitment is not fully understood, and a role for phenotypic transcription factors in the initial stages of hESC differentiation remains to be explored. From a screen of candidate factors, we found that RUNX1 is selec...

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Hlavní autoři:	Jennifer J. VanOudenhove, Ricardo Medina, Prachi N. Ghule, Jane B. Lian, Janet L. Stein, Sayyed K. Zaidi, Gary S. Stein
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2016-11-01
Edice:	Stem Cell Reports
Témata:	RUNX1 TGFB2 SMAD2 epithelial-mesenchymal transition mesendodermal differentiation human embryonic stem cells lineage commitment cell motility transcriptome profiling
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213671116302120
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