Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but their immunomodulatory mechanisms are unclear. W...

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Detaylı Bibliyografya

Asıl Yazarlar:	Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2024-02-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	cystatin dendritic cells immunomodulation mevalonate pathway transcriptome
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1328401/full
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