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Higher affinities of fibers with cell receptors increase the infection capacity and virulence of human adenovirus type 7 and type 55 compared to type 3

ABSTRACT Human adenovirus (HAdV) type 7 and type 55 infections cause more severe pneumonia than type 3 infections. However, the underlying mechanisms remain unclear. This study provided evidence linking the receptor-binding protein, fiber, to the stronger virulence of HAdV-55 and HAdV-7. Wild-type H...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Qiong Zhang, Zhichao Zhou, Ye Fan, Tiantian Liu, Yubing Guo, Xiao Li, Wenkuan Liu, Liling Zhou, Yujie Yang, Chuncong Mo, Yong Chen, Xiaohong Liao, Rong Zhou, Zhenhua Ding, Xingui Tian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2024-01-01
Schriftenreihe:Microbiology Spectrum
Schlagworte:
respiratory viruses
adenoviruses
receptors
pneumonia
virulence
pathogenesis
Online-Zugang:https://journals.asm.org/doi/10.1128/spectrum.01090-23
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