A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta deposition, the second main hallmark of AD, on human tau pat...

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Κύριοι συγγραφείς:	Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2023-01-01
Σειρά:	Alzheimer’s Research & Therapy
Θέματα:	Alzheimer’s disease Animal model Tau Knock-in Amyloid Gene expression
Διαθέσιμο Online:	https://doi.org/10.1186/s13195-022-01144-y
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