Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling
Abstract Achondroplasia, associated with gain-of-function mutations in FGFR3, causes growth plate cartilage dysfunction, resulting in short-limb dwarfism. However, its precise molecular and cellular mechanisms remain unclear. To address this, we aimed to generate knock-in mice (Fgfr3 Ach ) harboring...
I tiakina i:
| Ngā kaituhi matua: | , , , , , , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
Nature Portfolio
2026-02-01
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| Rangatū: | Nature Communications |
| Urunga tuihono: | https://doi.org/10.1038/s41467-026-69507-9 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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