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Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study

Abstract Background Physical loading is necessary to maintain bone tissue integrity. Loading-induced fluid shear is recognised as one of the most potent bone micromechanical cues and has been shown to direct stem cell osteogenesis. However, the effect of pressure transients, which drive fluid flow,...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault, David A. Hoey
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-10-01
Schriftenreihe:Stem Cell Research & Therapy
Schlagworte:
Mesenchymal stem cell
Bone
Mechanobiology
Osteogenic differentiation
Bioreactor
Online-Zugang:http://link.springer.com/article/10.1186/s13287-018-1025-8
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