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Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for alternative pathways is important. Recently, we r...

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Hlavní autor: Christian Humpel
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer Medknow Publications 2022-01-01
Edice:Neural Regeneration Research
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On-line přístup:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=9;spage=1881;epage=1884;aulast=Humpel
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