Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn

Alpha-synuclein (αsyn) misfolding and aggregation underlie several neurodegenerative disorders, including Parkinson’s disease. Early oligomeric intermediates are particularly toxic yet remain challenging to detect and characterize within cellular systems. Here, we employed the luminescent conjugated...

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Prif Awduron:	Priyanka Swaminathan, Karsten Sættem Godø, Eline Bærøe Bjørn, Therése Klingstedt, Debdeep Chatterjee, Per Hammarström, Rajeevkumar Raveendran Nair, Mikael Lindgren
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2025-10-01
Cyfres:	Cells
Pynciau:	alpha-synuclein Parkinson’s disease pre-formed fibrils A53T mutation fibrillation kinetics assay ThT
Mynediad Ar-lein:	https://www.mdpi.com/2073-4409/14/19/1542
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!