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THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia–reperfusion injury by inducing ferroptosis in endothelial cells

Abstract Macrophages play a critical role in the development of acute ischemic stroke (AIS). Cerebral ischemia–reperfusion injury (CIRI) is a pivotal pathological process that exacerbates AIS, with exosomes act as crucial mediators. However, the effects and mechanisms of action of macrophage-derived...

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Principais autores: Chang Liu, Haijing Sui, Zhixi Li, Zhenyu Sun, Chenglong Li, Guangmin Chen, Zhaoxue Ma, Hang Cao, Hongjie Xi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-02-01
coleção:Journal of Neuroinflammation
Assuntos:
Ischemic stroke
Cerebral ischemia–reperfusion injury
Macrophage
Endothelial cells
Exosomes
Acesso em linha:https://doi.org/10.1186/s12974-025-03382-x
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