Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell death. Interestingly, enhanced vulnerability to c...

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Manylion Llyfryddiaeth

Prif Awduron:	Anne Eckert, Katharina Schindowski, Silke Leutner, Christian Luckhaus, Nathalie Touchet, Christian Czech, Walter E. Müller
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2001-04-01
Cyfres:	Neurobiology of Disease
Pynciau:	Alzheimer's disease presenilin-1 cell death calcium oxidative stress lymphocytes
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S0969996100903784
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