Transcriptional regulation of genes by MYCN in PAX3::FOXO1-positive rhabdomyosarcomas and their roles in cell cycle progression

Background: MYCN amplification and high expression is associated with pediatric malignancies including neuroblastoma and alveolar rhabdomyosarcoma. MYCN transcription in alveolar rhabdomyosarcomas is driven by a feedback loop with the PAX3::FOXO1 fusion protein. However, the role of MYCN is not well...

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Hlavní autoři:	Zoë S. Walters, Daniel Leongamornlert, Barbara Villarejo-Balcells, Carmen Tse, Reuben Pengelly, Ian Titley, Janet Shipley
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-06-01
Edice:	EJC Paediatric Oncology
Témata:	MYCN ChIP-sequencing Cell cycle Rhabdomyosarcoma CDK6 KDM4B
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2772610X25000170
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