Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung

The mechanism that lung epithelial cells regulate immune responses during chronic injury still remains unclear. Here, we combined single-cell RNA sequencing with spatial transcriptomics to track epithelial dynamics in silica (SiO2)-exposed mouse lungs. By day 56, SiO2 induced significant epithelial...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Tao Wang, Jianfeng Hao, Bing Li, Ahjol Hyraht, Jialing Wang, Henglei Xia, Qingbin Wu, Wei Gao, Congxia Chen, Chuanqing Yu, Xiuqun Gong, Ting Li, Mei Zhang, Yinghai Xie, Xinrong Tao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-06-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	silicosis alveolar epithelial cells single-cell RNA sequencing spatial transcriptomics epithelial-immune crosstalk
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609616/full
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