IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC.

TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC. However, little is known about the distribution of RNA 5hmC and the regulatory mechanism...

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Principais autores:	Qiang Xu, Kai Wang, Lina Wang, Yuting Zhu, Guangyu Zhou, Dan Xie, Qingkai Yang
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2016-01-01
叢編:	PLoS ONE
在線閱讀:	http://europepmc.org/articles/PMC4993491?pdf=render
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