Structural implications for selective targeting of PARPs

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD+ as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins. PARPs have important cellular roles that include preserving genomic integrity, telomere maintenance, transcriptional r...

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書誌詳細

主要な著者:	Jamin D. Steffen, Jonathan R. Brody, Roger S. Armen, John Matteson Pascal
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2013-12-01
シリーズ:	Frontiers in Oncology
主題:	Poly(ADP-ribose) Polymerases chemotherapeutics DNA damage signalling PARP inhibitors poly(ADP-ribosyl)ation
オンライン･アクセス:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00301/full
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