A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression

Abstract Background Our previous genome‑wide association studies (GWAS) have suggested rs912304 in 14q12 as a suggestive risk variant for type 1 diabetes (T1D). However, the association between this risk region and T1D subgroups and related clinical risk features, the underlying causal functional va...

Descrición completa

Detalles Bibliográficos

Principais autores:	Yu Qian, Shu Chen, Yan Wang, Yuyue Zhang, Jie Zhang, Liying Jiang, Hao Dai, Min Shen, Yunqiang He, Hemin Jiang, Tao Yang, Qi Fu, Kuanfeng Xu
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-09-01
Series:	BMC Medicine
Assuntos:	T1D Stxbp6 Islet function Islet autoimmunity Variant
Acceso en liña:	https://doi.org/10.1186/s12916-024-03583-w
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!