mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation, and metabolic failure in the retinal pigment epithe...

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Autors principals:	David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-12-01
Col·lecció:	Antioxidants
Matèries:	retinal pigment epithelium (RPE) cells age-related macular degeneration (AMD) complement factor H (<i>CFH</i>/FH) mammalian target of rapamycin (mTOR) mitochondrial respiration interactome
Accés en línia:	https://www.mdpi.com/2076-3921/10/12/1944
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