Genomic Context Differs Between Human Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy

Background Inherited cardiomyopathies display variable penetrance and expression, and a component of phenotypic variation is genetically determined. To evaluate the genetic contribution to this variable expression, we compared protein coding variation in the genomes of those with hypertrophic cardio...

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Detalhes bibliográficos

Principais autores:	Megan J. Puckelwartz, Lorenzo L. Pesce, Lisa M. Dellefave‐Castillo, Matthew T. Wheeler, Tess D. Pottinger, Avery C. Robinson, Samuel D. Kearns, Anthony M. Gacita, Zachary J. Schoppen, Wenyu Pan, Gene Kim, Jane E. Wilcox, Allen S. Anderson, Euan A. Ashley, Sharlene M. Day, Thomas Cappola, Gerald W. Dorn, Elizabeth M. McNally
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2021-04-01
coleção:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	dilated cardiomyopathy hypertrophic cardiomyopathy modifier genes variable expressivity variant burden
Acesso em linha:	https://www.ahajournals.org/doi/10.1161/JAHA.120.019944
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