Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins

Abstract Iron is an essential nutrient for most bacteria and is often growth-limiting during infection, due to the host sequestering free iron as part of the innate immune response. To obtain the iron required for growth, many bacterial pathogens encode transporters capable of extracting the iron-co...

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Hlavní autoři:	Daniel R. Fox, Kazem Asadollahi, Imogen Samuels, Bradley A. Spicer, Ashleigh Kropp, Christopher J. Lupton, Kevin Lim, Chunxiao Wang, Hari Venugopal, Marija Dramicanin, Gavin J. Knott, Rhys Grinter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-07-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-60612-9
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