Human umbilical cord-derived mesenchymal stem cells ameliorate non-alcoholic fatty liver disease via activating TFEB-mediated autophagy in male mice

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal lipid accumulation in hepatocytes and defective autophagy has been implicated in its pathogenesis. Human umbilical cord-derived MSCs (hUC-MSCs) have shown therapeutic potential in treating NAFLD, while underly...

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Auteurs principaux:	Huina Zhang, Peng Liu, Yaxuan Deng, Li Wu, Orion Fan, Yanling Cui, Chunxue Zhang, Wenmin Zhu, Yi Eve Sun, Chuwen Lin, Congrong Wang
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-12-01
Collection:	Stem Cell Research & Therapy
Sujets:	NAFLD Autophagy hUC-MSCs Transcription factor EB
Accès en ligne:	https://doi.org/10.1186/s13287-025-04855-9
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