Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia

<b>Background/Objectives</b>: GFI1-36N represents a single-nucleotide polymorphism (SNP) of the zinc finger protein Growth Factor Independence 1 (GFI1), in which the amino acid serine (S) is replaced by asparagine (N). The presence of the <i>GFI1-36N</i> gene variant is associated with a reduced DNA...

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Detalhes bibliográficos

Principais autores:	Jan Vorwerk, Longlong Liu, Theresa Helene Stadler, Daria Frank, Helal Mohammed Mohammed Ahmed, Pradeep Kumar Patnana, Maxim Kebenko, Eva Dazert, Bertram Opalka, Nikolas von Bubnoff, Cyrus Khandanpour
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-01-01
Colecção:	Biomedicines
Assuntos:	acute myeloid leukemia GFI1 single-nucleotide polymorphism metabolism ROS
Acesso em linha:	https://www.mdpi.com/2227-9059/13/1/107
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