The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation

The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced Aβ aggregation implicated in Alzheimer’s disease (AD) pathogenesis. The histidine to arginine substitution at position 6 of the Aβ sequence (H6R, English mutation) leads to an e...

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Principais autores:	Sergey P. Radko, Svetlana A. Khmeleva, Dmitry N. Kaluzhny, Olga I. Kechko, Yana Y. Kiseleva, Sergey A. Kozin, Vladimir A. Mitkevich, Alexander A. Makarov
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2020-06-01
Serija:	Biomolecules
Teme:	amyloid-β English mutation zinc aggregation
Online dostop:	https://www.mdpi.com/2218-273X/10/6/961
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