Isogenic induced pluripotent stem cell line ICGi036-A-1 from a patient with familial hypercholesterolaemia, derived by correcting a pathogenic variant of the gene LDLR c.530C>T

Familial hypercholesterolaemia is a common monogenic disorder characterized by high plasma cholesterol levels leading to chronic cardiovascular disease with high risk and often early manifestation due to atherosclerotic lesions of the blood vessels. The atherosclerotic lesions in familial hyperchole...

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Hauptverfasser:	A. S. Zueva, A. I. Shevchenko, S. P. Medvedev, E. A. Elisaphenko, A. A. Sleptcov, M. S. Nazarenko, N. A. Tmoyan, S. M. Zakian, I. S. Zakharova
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2025-04-01
Schriftenreihe:	Вавиловский журнал генетики и селекции
Schlagworte:	семейная гиперхолестеринемия ldlr индуцированные плюрипотентные стволовые клетки геномное редактирование изогенные линии клеток
Online-Zugang:	https://vavilov.elpub.ru/jour/article/view/4537
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