Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors

Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate (pyrimidine) scaffold, here we tested the capacity of...

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Hlavní autoři:	M. Ali, Assem Barakat, Ayman El-Faham, Abdullah Mohammed Al-Majid, Sammer Yousuf, Sajda Ashraf, Zaheer Ul-Haq, M. Iqbal Choudhary, Beatriz G. de la Torre, Fernando Albericio
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-05-01
Edice:	Applied Sciences
Témata:	pyrimidine-trione barbituric thiobarbituric urease inhibitors DFT
On-line přístup:	https://www.mdpi.com/2076-3417/10/10/3523
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