Latent-profile analysis of sleep disturbances, cognitive performance and neuropsychiatric symptoms reveals subtypes of Parkinson’s disease

ObjectiveGiven the clinical heterogeneity of Parkinson’s disease (PD), identification of early -stage subgroups with shared non-motor symptom (NMS) profiles may clarify its pathophysiology. This study used latent-profile analyses (LPA) to define subgroups based on sleep disturbances, cognitive perfo...

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Autors principals:	Lyna Mariam El Haffaf, Magdalena Eriksson Domellöf, Lucas Ronat, Oury Monchi, Lois Walton, David Bäckström, Carl-Johan Boraxbekk, Lars Forsgren, Lars Nyberg, Anna Stigsdotter Neely, Jarkko Johansson
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-03-01
Col·lecció:	Frontiers in Neurology
Matèries:	[11C]-raclopride PET cognitive performance neuropsychiatric symptoms Parkinson’s disease sleep disturbances
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fneur.2026.1765246/full
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