Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators

We describe the efficient synthesis of a series of new simplified hamigeran B and 1-hydroxy-9-epi-hamigeran B norditerpenoid analogs (23 new members in all), structurally related to cyathane diterpenoid scaffold, and their anti-neuroinflammatory and neurite outgrowth-stimulating (neurotrophic) activ...

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Bibliographic Details

Main Authors:	Ruo-Xin Li, Rui Han, Guo-Jie Wu, Fu-She Han, Jin-Ming Gao
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2020-06-01
Series:	Marine Drugs
Subjects:	nitric oxide inhibitor neurotrophic activity norditerpenoid analogues anti-neuroinflammatory activity structure-activity relationship
Online Access:	https://www.mdpi.com/1660-3397/18/6/306
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