Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs
A major complication of hemophilia A therapy is the development of alloantibodies (inhibitors) that neutralize intravenously administered coagulation factor VIII (FVIII). Immune tolerance induction therapy (ITI) by repetitive FVIII injection can eradicate inhibitors, and thereby reduce morbidity and...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2022-11-01
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| Schriftenreihe: | The Journal of Clinical Investigation |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1172/JCI159925 |
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